Lucian and his wife Daciana are the rulers of the race known as vrykolakas. They are the predecessors of the first vampires, but have remained more consistently in the shadows that their more well known cousins.

When Mammon came to them with a young creature he claimed would be their messiah, Lucian and Daciana raised it as their own and planned for their new age. They named the child Morana, after death itself, because of its insatiable hunger for blood and pain. She was not vrykolakas, nor was she human or vampire. She was something unknown to the world.

One of the three Miller boys of Malice, Pennsylvania. The Miller boys were known to be bullies by just about everyone, but no one knew just how dangerous that they had become except little Mikey Maloy.

The summer after Urizen, the Miller boys were playing on the Devil's Right Hand and a small shard of the rock went into Preston's foot. He somehow absorbed or released a portion of Urizen's power and shared it with his brothers. Suddenly, they found they could do things with their minds - like making their teacher almost choke to death.

On Halloween, the boys slaughtered pigs and wore their heads as masks to torment little Mikey. Preston lost control of the evil and began to morph into a monster, but Spawn arrived and forced Urizen out of him.

After that day, Preston was terrified of the dark and unable to leave his home, while his brothers never spoke again.

One of three young men found in an abandoned house with a murdered young woman. When Spawn discovered them, He demanded to be told the truth about what happened.

He was told 3 different stories, and after deliberating, he offered the murder-knife to the young man named Danny. He told Danny to deliver justice to the other two for what they had done. Danny proceeded to murder the other two, after which Spawn revealed he knew the truth all along - that Danny was not innocent. He then dragged Danny off for his own, much worse, punishment.

One of the three Miller boys of Malice, Pennsylvania. The Miller boys were known to be bullies by just about everyone, but no one knew just how dangerous that they had become except little Mikey Maloy.

The summer after Urizen, the Miller boys were playing on the Devil's Right Hand and a small shard of the rock went into Preston's foot. He somehow absorbed or released a portion of Urizen's power and shared it with his brothers. Suddenly, they found they could do things with their minds - like making their teacher almost choke to death.

On Halloween, the boys slaughtered pigs and wore their heads as masks to torment little Mikey. Preston lost control of the evil and began to morph into a monster, but Spawn arrived and forced Urizen out of him.

After that day, Preston was terrified of the dark and unable to leave his home, while his brothers never spoke again.

Tremor's brother. David was "rescued" by the mafia after his family was murdered (Twistelli in fact ordered their murders). Like his brother before him, David went to work for Twistelli. When Tremor returned to get revenge on Twistelli, he found that his brother David was protecting the mob boss.

David was unable to recognize Tremor as his brother and shot him multiple times. Tremor was saved by Spawn, who attacked David, who then in turn was saved by Tremor, who pleaded with Spawn to spare his brother. In the end, Spawn and Tremor left to get medical attention for David.

A teenage girl who claimed to be emancipated, who met Max Williams in an arcade. The two hit it off and spent the whole day together, after which they were nearly inseparable.

Dawn was a member of The Kingdom and she groomed Max to become a member as well. When she felt he was ready, she bit her own lip and had Max drink her blood, which began his transformation into a vampire.

Scared and ill, Max became angry with Dawn, but she claimed she wanted him to join her only because she cared for him. As she tried to explain herself but before she could finish transforming Max, she was killed by the demons Ab and Zab.

According to Malebolgia, there are several Dead Zones - neutral starting points from which Hell places Heaven's agents, and Heaven places Malebolgia's hellspawn. Within the zones, all of a soul's powers are neutralized and everything is invisible to the eyes of mankind.

Over the years, both Heaven and Hell have sought to protect their own Dead Zones while trying to learn the locations of the opposing side's zones. Heaven had an ongoing relationship with the humans of the United States, including Jason Wynn.

Likewise, Hell also had working relationships with humans to protect their zones. At one point, they made a bargain with Jason Wynn to "switch sides" and assist them instead of Heaven.

According to Cogliostro, the specific Dead Zone in Rat City was a celestial safe zone - a small patch of Heaven on earth amid the alleys. It was able to hold back the power of Hell, even Spawn's powers, and thus it could be a dangerous place for a hellspawn.

Indeed it was dangerous for Al Simmons, who was brutally attacked there a number of times by the likes of the Violator, the Disciple, the Heap, Billy Kincaid, and the vampire Wolfram.

However, Spawn learned from Mother that the Dead Zone in his alleys was not a just a portal to Heaven as Cog had believed, but also a portal to Eden.

Later, the alley Dead Zone seemed to have no effect on the heavenly powers of Jim Downing, much to the dismay of Malebolgia. Downing seemed to find himself drawn to the location without ever realizing why.

His attraction to the Dead Zone led to its discovery by Bludd, who immediately recognized it as his opportunity to reach Heaven. Bludd planned to create an army to storm the gates of Heaven and eventually attack God himself. He began his plan by building a fortress (in the guise of a charity organization) around the Dead Zone to protect it and keep it hidden.

As Downing learned more about the Dead Zone, he discovered that its soil could be weaponized in a way - sprinkling it over an enemy seemed to neutralize their powers for a time.

After the return of Al Simmons as Spawn, the alley Dead Zone was also used as a passageway directly to Hell. Eventually, Spawn sealed all of the Dead Zones, trapping any visiting Angels and Demons on Earth.
 
This changed the entire power structure on Earth, as forces from Heaven and Hell were cut off from their superiors, and forced to live full-time amongst the humans.