- There are 23 versions of this issue, including variant covers, additional printings, and exclusives.
- This is cover "H" by Todd McFarlane, one of 16 covers that were distributed evenly. It is an homage to Amazing Spider-Man 300, also by McFarlane.
- Spawn 301 is the 1st creator-owned US comic to ever reach issue 301.
Spawn reveals new powers to the Violator as he unleashes his master plan. Elsewhere, Spawn's efforts have awakened many other players in the game, as he continues to hunt down agents of Heaven and Hell.
